Prof. dr hab. Piotr Mariusz Skowron (University of Gdansk) has received National Center for Science (NCN) grant in the amount of 2,197,200 PLN for the development of novel gene expression system, based on thermophilic bacteriophages entitled: “Synthetic biology approach to biosynthesis of termophilic, problematic and toxic protein: bacteriophage expression system with very wide temperature range (30-80).”. Cloning and expression of genes in heterologous organisms, synthetic biology, and recombinant proteins have become indispensable tools in scientific research and the biotechnology industry. However, some essential areas of gene cloning/expression suffer from major deficiencies, such as problems with protein biosynthesis from recombinant genes. Selected concepts of of the DNA FACE™ technology will be applied in prospective genetic constructs.
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The DNA FACE™ concept has been successfully used to develop prototype pro-regenerative drug. The EP 3.549.947.B1 patent is a result of long-term scientific cooperation and partnership between BioVentures Institute, University of Gdańsk, Gdańsk Medical University and Gdańsk Technical University financed by R&D grant from The National Centre for Research and Development STRATEGMED1/235077/9/NCBR/2014 (2014-2017): “Novel technologies for pharmacological stimulation of regeneration.”
One of the leading current trends in technology is the miniaturization of devices to the microscale and nanoscale. The highly advanced approaches are based on biological systems, subjected to bioengineering using chemical, enzymatic and recombinant methods. We have utilized the biological affinity towards cellulose of the cellulose binding domain (CBD) fused with recombinant proteins for the generation of functionalized microparticles, approaching nanoscale. This publication is a result of long-term scientific cooperation and partnership between BioVentures Institute, University of Gdańsk, Gdańsk Medical University and Gdańsk Technical University financed by R&D grant from The National Centre for Research and Development TECHMATSTRATEG2/410747/11/NCBR/2019 (2019-2022): „New generation bioactive molecules delivery systems, based on chemically synthesized and obtained through genetic engineering” is dedicated to the construction of several classes of novel bionanoparticles fused with concatemeric proteins, based on DNA-FACE™.
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